From the confirmed mechanism of action, NMN is specially transported into cells by slc12a8 transporter on small intestine cells, and increases the level of NAD+ in various organs and tissues of the body along with blood circulation.
However, NMN is easily degraded after moisture and temperature reach a certain height. At present, most of the NMN on the market are capsules and tablets. After taking NMN capsules or tablets, most of them are degraded in the stomach, and only a small part of NMN reaches the small intestine.
● What is liposomal NMN ?
Liposomes are spherical "sacs" made of dicyclic fatty acid molecules called phosphatidylcholine molecules (phospholipids attached to choline particles). Liposome spherical "sacs" can be used to encapsulate nutritional supplements such as NMN and deliver them directly into cells and body tissues.
A phospholipid molecule consists of a hydrophilic phosphate head and two hydrophobic fatty acid tails. This makes the liposome a carrier of hydrophobic and hydrophilic compounds. Liposomes are lipid vesicles made of phospholipids strung together to form a double-layer membrane, just like almost all cell membranes in our bodies.
● How does liposome NMN work in the body?
In the first stage of liposome-cell interaction, liposome NMN adheres to the cell surface. In this binding, liposome NMN is internalized into the cell through an endocytosis (or phagocytosis) mechanism. Following enzymatic digestion in the cellular compartment, NMN is released into the cell, restoring the original nutritional activity.
The purpose of taking any supplement is to ensure that it enters the bloodstream through mucous membranes and intestinal epithelial cells. However, due to the low absorption rate and bioavailability of traditional NMN forms, the active ingredient loses most of its potency as it passes through the gastrointestinal tract, or is not absorbed by the small intestine at all.
When NMN is combined with liposome, it is more conducive to the transportation of NMN and the bioavailability is greatly improved.
Targeted delivery
Unlike all other NMN morphological delivery methods, liposomal NMN has a delayed release function, which increases the circulation time of key nutrients in the blood and significantly improves bioavailability.
The higher the bioavailability of an active substance, the greater its effect on the body.
Advanced absorption
Liposome NMN is absorbed through lymphatic mechanisms in the mucosal lining of the mouth and intestine, bypishing first-pass metabolism and decomposition in the liver, ensuring the preservation of liposome NMN integrity. Synthesis is performed to make NMN easier to transport to various organs.
This higher absorption means higher efficacy and smaller doses for better results.
Biocompatibility
Found in cell membranes throughout the body, phospholipids are naturally present, and the body recognizes them as compatible with the body and does not see them as "toxic" or "foreign" - and therefore, does not launch an immune attack against liposomal NMN.
Masking
Liposomes protect NMN from detection by the body's immune system, mimicking biofilms and giving the active ingredient more time to reach its intended destination.
Phospholipids mask the active ingredients so that more amounts can be absorbed and escape the selective function of the small intestine.
Cross the blood-brain barrier
Liposomes have been shown to cross the blood-brain barrier, enabling liposomes to deposit NMN directly into cells and enhance nutrient circulation through the lymphatic system.
● NEWGREEN Supply NMN Powder/Capsules/Liposomal NMN
Post time: Oct-22-2024
