Newgreen Supply Pharmaceutical 99% Purity Metallothionein Powder Material Metallothionein Mt Rabbit Liver Zinc Metallothionein
Product Description
Metallothionein is a low molecular weight protein with metal binding ability and high induction properties. [1] Short peptides rich in cysteine with high affinity for a variety of heavy metals. It is a protein with low molecular weight and extremely high content of cysteine residues and metals. The combined metals are mainly cadmium, copper and zinc, which are widely present in various organisms from microorganisms to humans, and their structure is highly conserved.
COA
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ITEMS |
STANDARD |
TEST RESULT |
| Assay | 98%min Metallothionein | Conforms |
| Color | White Powder | Conforms |
| Odor | No special smell | Conforms |
| Particle size | 100% pass 80mesh | Conforms |
| Loss on drying | ≤5.0% | 2.35% |
| Residue | ≤1.0% | Conforms |
| Heavy metal | ≤10.0ppm | 7ppm |
| As | ≤2.0ppm | Conforms |
| Pb | ≤2.0ppm | Conforms |
| Pesticide residue | Negative | Negative |
| Total plate count | ≤100cfu/g | Conforms |
| Yeast & Mold | ≤100cfu/g | Conforms |
| E.Coli | Negative | Negative |
| Salmonella | Negative | Negative |
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Conclusion |
Conform with Specification |
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Storage |
Stored in Cool & Dry Place, Keep Away From Strong Light And Heat |
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Shelf life |
2 years when properly stored |
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Function
MT is a metal-binding protein rich in cysteine. Its sulfhydryl group can strongly chelate toxic metals and excrete them from the body, thereby achieving detoxification. [4] MT is related to the metabolism of trace metals. In all mammalian tissues, MT-1 and MT-2 are expressed synergistically. MT-3 is a specific member of the brain in this family. It can bind zinc and copper and has important neurophysiological and neuromodulation functions. Studies on many aquatic organisms have shown that MT plays an important role in the regulation of basic metal elements, and has inhibitory and detoxifying effects on non-basic metal elements. MT can effectively reduce the toxicity of heavy metals to the body by combining with heavy metals, and it is currently the most ideal biological chelating antidote in clinical practice.
Environmental protection
Utilizing the characteristics of the combination of MT and metal, it is possible to breed or use genetic engineering to establish a high expression system of MT to control heavy metal pollution. According to reports, tobacco transfected with yeast MT gene can significantly increase the absorption of cu2 in contaminated soil, and this method can be used to remedy areas contaminated by heavy metals.
MT and radiation resistance
Ionizing radiation can produce a large amount of free radicals, which can damage organisms directly or indirectly. Studies have shown that oral administration of MT can prolong the survival time of mice exposed to a one-time high-dose ionizing radiation, and reduce the damage to the immune system caused by one-time high-dose and multiple low-dose ionizing radiation. Oral MT can absorb a large amount of Cys that enters the body. It provides raw materials for repairing the disulfide bonds broken by radiation in the body.
MT and Parkison (PD) disease
Many experiments have proved that MT has a protective effect on the nervous system. Experiments have shown that in transgenic mice, overexpression of MT-1 can change the symptoms of encephalitis and promote brain repair. It is a protective factor in nerve cells. Through the study of rat stabbing model and ischemia model, it is found that MT-3 is involved in the repair of central nervous system damage. PD disease is caused by the induction of free radicals by 6-hydroxydopamine, and certain inducers of MT isoforms in the brain, such as oxidative stress, cytokines and inflammatory processes, can prevent this neurotoxicity, which is free from MT clearance Base related.
Applications
Metallothionein (MT) is a kind of low molecular protein rich in cysteine and metal. Due to its ability to bind a large number of metal ions and its special physiological function, it has been paid more attention in the field of biochemistry. The research history of MT has been more than 40 years, and the research on its structure, characteristics, gene regulation and biological function has been increasingly in-depth. The application prospects of MT are very broad, including but not limited to:
1. Medical field : MT is mainly clinically applied in cardiovascular and cerebrovascular diseases and tumors, but has not been applied in epilepsy.
2. Food health and cosmetic additive : MT can be used as an additive in foods, health supplements and cosmetics to provide additional health benefits.
3. Genetic engineering reagent : In genetic engineering, MT is used as a reagent to promote the research and application of genetic engineering.
4. Chemical and environmental protection : MT is also used in chemical and environmental protection fields, for example to remove harmful metals.
agricultural laboratory articles : MT can be used as an experimental article in agricultural experiments, especially in the study of heavy metal pollution and plant tolerance to heavy metals.
5. In addition, MT also has the function of participating in the storage, transportation and metabolism of trace elements zinc and copper, detoxification of heavy metal elements cadmium, mercury and lead, antagonizing ionizing radiation and removing hydroxyl free groups. Natural MT genes have been cloned into tobacco, petunia and other plants by genetic engineering, and the transgenic plants showed high resistance to cadmium pollution. If the MT gene is transferred into clover and duckweed and planted in the land or water polluted by cadmium and mercury, it can absorb a large number of toxic metals in the soil and water, and play a role in removing harmful metals .
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