Newgreen Supply Isocorydine 98%
Product Description：
Isocorydine is a compound with various pharmacological effects, mainly exists in the Chinese medicine Zijinlong, is a white powder, soluble in methanol, ethanol, DMSO and other organic solvents. isocorydine is derived from the Corydalis tuberosa DC. (Corydalis tuberosa DC.) . The compound has antiarrhythmic, vasodilating and antihypoxia effects, showing its potential in medical applications.
Studies on drug metabolism and kinetics of isocoridine in human body show that after absorption in the intestinal tract, 10% enters the intestinal wall in a free state, 90% binds to mucosal cells, is then transported to hepatocytes through the liver, and is distributed in various organs of the body. its metabolic pathway is largely through the liver, metabolites including different purple pansy, grass glucoside II, zhang terpene alcohols, , needles hydroxyl different alkali and purple pansy, including hydroxyl different purple pansy base has better pharmacological activities, long half-life, can slow release, effect more enduring.
COA：
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ITEMS |
STANDARD |
TEST RESULT |
| Assay | 98% Isocorydine | Conforms |
| Color | White Powder | Conforms |
| Odor | No special smell | Conforms |
| Particle size | 100% pass 80mesh | Conforms |
| Loss on drying | ≤5.0% | 2.35% |
| Residue | ≤1.0% | Conforms |
| Heavy metal | ≤10.0ppm | 7ppm |
| As | ≤2.0ppm | Conforms |
| Pb | ≤2.0ppm | Conforms |
| Pesticide residue | Negative | Negative |
| Total plate count | ≤100cfu/g | Conforms |
| Yeast & Mold | ≤100cfu/g | Conforms |
| E.Coli | Negative | Negative |
| Salmonella | Negative | Negative |
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Conclusion |
Conform with Specification |
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Storage |
Stored in Cool & Dry Place, Keep Away From Strong Light And Heat |
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Shelf life |
2 years when properly stored |
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Analyzed by: Liu Yang Approved by: Wang Hongtao
Function:
Isocorydine has many pharmacological effects such as relieving epidemic disease, dilating blood vessels, anti-disease and anti-arrhythmia. As early as the century, some scholars have carried out research on the biological activity of isocorydine. The pharmacological experiments of D-isocorydine were carried out in children, mice, rabbits, cats, dogs and other animals. The results showed that the effect intensity of isocorydine was related to the drug quantity and species. For frog and mouse, the pharmacological effect of small dose is weak, and large dose can cause convulsion; In cats and dogs, medium dose produces anthematous lethargy, while large dose causes hyperactivity. In the last century, a large number of experiments found that isocorydine affected the ileum, ductus deferens, common bile duct, gallbladder, semen, biliary sphincter, duodenum, biliary sphincter, aorta, portal vein, bovine coronary artery, etc., in guinea pigs. The in vivo visceral smooth muscle of many species, such as mouse vas deferens and rat uterus, has non-specific cisternocytic effect, and its antispasmodic strength is close to that of sobritarine.
Application:
The main applications of isocyanidine include the treatment of pain caused by spasm of gastrointestinal, bile, pancreas, uterus, blood vessels, inhibit the proliferation of cervical cancer cells, and reduce the level of uric acid in blood.
1. Treatment of spasm pain: isocorydine is a kind of drug, is mainly used for the treatment of pain caused by spasm of gastrointestinal, bile, pancreas, uterus, blood vessels and so on.
2. Inhibit the proliferation of cervical cancer cells: D-isocorydione (Isocorydione) has a significant inhibitory effect on the proliferation of human cervical cancer SiHa cells. In vitro intervention of SiHa cells with different concentrations of D-isocorydine was performed on human cervical cancer siHA cells. The results () showed that could significantly inhibit cell proliferation, and promote cell apoptosis, this action is related to mitochondrial apoptotic pathway proteins.
3. Lowering blood uric acid levels: isocorydine or its salts are useful in the preparation of medicines or health products to lower blood uric acid levels. Animal experiments show that isocyanidine can significantly reduce the level of uric acid in blood, and improve the degree of renal tubule dilatation, necrosis and renal fibrosis in hyperuricemia mice. provides a new drug choice for the clinical treatment of hyperuricemia and its induced hyperuricemia nephropathy.
In summary, isocyanidine has wide application value in the field of medicine, can not only treat spasm pain, can effectively inhibit the proliferation of cervical cancer cells, can also help to reduce the blood uric acid level, provides a new solution for the treatment of related diseases.
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