Newgreen Factory Supply Topotecan Hydrochloride High Quality 99% Topotecan Hydrochloride Powder
Product Description
Topotecan Hydrochloride is a chemotherapy drug used primarily to treat certain types of cancer. It is the hydrochloride form of topotecan, a topoisomerase inhibitor that works primarily by inhibiting the activity of DNA topoisomerase I.
Notes:
When using Topotecan, patients should be under the guidance of a doctor, especially for patients with liver and kidney dysfunction or other health problems. Regular blood tests are required during treatment to monitor possible side effects.
In conclusion, Topotecan Hydrochloride is an important anticancer drug, mainly used to treat ovarian cancer and small cell lung cancer, and has significant clinical application value.
COA
| Items | Specifications | Results |
| Appearance | Off-white or white powder | White Powder |
| HPLC Identification | Consistent with the reference
substance main peak retention time |
Conforms |
| Specific rotation | +20.0。-+22.0。 | +21。 |
| Heavy metals | ≤ 10ppm | <10ppm |
| PH | 7.5-8.5 | 8.0 |
| Loss on drying | ≤ 1.0% | 0.25% |
| Lead | ≤3ppm | Conforms |
| Arsenic | ≤1ppm | Conforms |
| Cadmium | ≤1ppm | Conforms |
| Mercury | ≤0. 1ppm | Conforms |
| Melting point | 250.0℃~265.0℃ | 254.7~255.8℃ |
| Residue on ignition | ≤0. 1% | 0.03% |
| Hydrazine | ≤2ppm | Conforms |
| Bulk density | / | 0.21g/ml |
| Tapped density | / | 0.45g/ml |
| Assay（Topotecan Hydrochloride） | 99.0%~ 101.0% | 99.65% |
| Total aerobes counts | ≤1000CFU/g | <2CFU/g |
| Mould & Yeasts | ≤100CFU/g | <2CFU/g |
| E.coli | Negative | Negative |
| Salmonella | Negative | Negative |
| Storage | Store in cool & drying place, keep away strong light. | |
| Conclusion | Qualified | |
Function
Topotecan Hydrochloride is a chemotherapy drug used primarily to treat certain types of cancer. It is a topoisomerase inhibitor with the following specific mechanisms of action and functions:
Function:
1.Topoisomerase inhibition: Topotecan interferes with DNA replication and transcription by inhibiting the activity of topoisomerase I. This inhibition leads to the breakage of DNA chains, thereby preventing the proliferation of cancer cells.
2.Antitumor activity: Topotecan is mainly used to treat ovarian cancer, small cell lung cancer and certain types of lymphoma. It can be used as first-line treatment or as a second-line treatment after other treatments have failed.
3.Cell cycle specificity: Topotecan's effect on the cell cycle mainly occurs in the S phase and G2 phase, which makes it have a strong killing effect on cancer cells in a specific cell proliferation stage.
4.Combination therapy: Topotecan can be used in combination with other chemotherapy drugs to enhance the anti-tumor effect and improve the patient's treatment response.
5.Relieve Symptoms: In some cases, the use of Topotecan can help relieve cancer-related symptoms and improve the patient's quality of life.
Notes:
Topotecan may cause some side effects, including but not limited to nausea, vomiting, fatigue, leukopenia, etc. When using this drug, patients need to be monitored and managed under the guidance of a doctor.
In conclusion, Topotecan Hydrochloride is an effective anticancer drug that exerts its antitumor effects primarily through inhibition of DNA topoisomerase I.
Application
Topotecan Hydrochloride is a chemotherapy drug used primarily to treat certain types of cancer. The following are its main applications:
1.Ovarian cancer: Topotecan is commonly used to treat recurrent ovarian cancer, especially in patients after other treatments (such as platinum-based chemotherapy) have failed. It can be used as a single agent or in combination with other drugs.
2.Small cell lung cancer: This drug is also used in the treatment of small cell lung cancer, usually as a second-line treatment option, especially when the disease relapses after initial chemotherapy.
3.Other Cancers: Although Topotecan is primarily used for ovarian cancer and small cell lung cancer, it is also being studied in some clinical trials for other types of cancer, such as cervical cancer, pancreatic cancer, and certain types of lymphoma.
4.Clinical trials: Topotecan is also being evaluated in clinical trials for various cancers to study its effectiveness and safety in different treatment options.
5.Combination Therapy: In some cases, Topotecan may be used in combination with other chemotherapy drugs or targeted therapy drugs to enhance the therapeutic effect.
Notes:
When using Topotecan, patients should be under the guidance of a doctor, especially for patients with liver and kidney dysfunction or other health problems. Regular blood tests are required during treatment to monitor possible side effects.
In conclusion, Topotecan Hydrochloride has important application value in cancer treatment, especially in the management of recurrent ovarian cancer and small cell lung cancer.
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