• Gịnị BụTetrahydrocurcumin ?
Rhizoma Curcumae Longae bụ rhizoma akọrọ nke Curcumae Longae L. A na-ejikarị ya eme ihe dị ka nri agba na isi ísì. Ngwakọta kemịkal ya gụnyere curcumin na mmanụ na-agbanwe agbanwe, ewezuga saccharide na sterols. Curcumin (CUR), dị ka polyphenol sitere n'okike na osisi curcuma, egosila na ọ nwere mmetụta dị iche iche nke ọgwụ, gụnyere mgbochi mkpali, antioxidant, ikuku oxygen free radical, nchebe imeju, mgbochi fibrosis, ọrụ mgbochi tumor na mgbochi. ọrịa Alzheimer (AD).
Curcumin na-eme ngwa ngwa metabolized n'ime ahụ n'ime glucuronic acid conjugates, sulfuric acid conjugates, dihydrocurcumin, tetrahydrocurcumin, na hexahydrocurcumin, nke n'aka nke na-agbanwe ghọọ tetrahydrocurcumin. Nnyocha nyocha ekwenyela na curcumin nwere nkwụsi ike na-adịghị mma (lee fotodecomposition), mmiri na-adịghị mma na-adịghị ala ala na bioavailability dị ala. Ya mere, akụrụngwa metabolic ya bụ tetrahydrocurcumin n'ime ahụ abụrụla ebe nyocha n'ụlọ na mba ofesi n'afọ ndị na-adịbeghị anya.
Tetrahydrocurcumin(THC), dị ka ihe kacha arụ ọrụ na isi metabolite nke curcumin emepụtara n'oge metabolism ya na vivo, enwere ike kewapụ ya na cytoplasm nke obere eriri afọ na imeju mgbe nchịkwa curcumin nye mmadụ ma ọ bụ òké. The molekụla usoro bụ C21H26O6, molekụla arọ bụ 372.2, njupụta bụ 1.222, na agbaze ebe bụ 95 ℃-97 ℃.
• Gịnị bụ uru nkeTetrahydrocurcuminNa Nlekọta anụahụ?
1. Mmetụta na mmepụta melanin
Tetrahydrocurcumin nwere ike ibelata ọdịnaya melanin na sel B16F10. Mgbe enyere mkpokọta tetrahydrocurcumin (25, 50, 100, 200μmol/L), ọdịnaya melanin belatara site na 100% ruo 74.34%, 80.14%, 34.37%, 21.40% n'otu n'otu.
Tetrahydrocurcumin nwere ike igbochi ọrụ tyrosinase na sel B16F10. Mgbe ntinye nke tetrahydrocurcumin (100 na 200μmol/L) kwekọrọ na mkpụrụ ndụ, ọrụ intracellular tyrosinase gbadara ruo 84.51% na 83.38% n'otu n'otu.
2. Mgbochi foto
Biko lee eserese òké n'okpuru: Ctrl (njikwa), UV (UVA + UVB), THC (UVA + UVB + THC THC100 mg/kg, etisasịwo na 0.5% sodium carboxymethyl cellulose). Foto nke akpụkpọ ahụ n'azụ ụmụ oke KM na izu iri ka emechara ọgwụgwọ THC na irradiation UVA. Otu dị iche iche nwere ụzarị ọkụ UVA dabara na ịka nká ka ejiri akara Bissett tụlere. Ụkpụrụ ndị a na-enye bụ ụkpụrụ ọkọlọtọ pụtara (N = 12/ otu). P <0.05, **P
Site na ọdịdị ahụ, ma e jiri ya tụnyere ndị na-ahụ maka njikwa nkịtị, akpụkpọ anụ nke ndị na-ahụ maka ihe nlereanya ahụ siri ike, erythema a na-ahụ anya, ọnya, wrinkles na-emewanyewanye ma na-agbatị, na-esonyere mgbanwe akpụkpọ anụ, na-egosi ihe ngosi fotoaging ahụkarị. Tụnyere ndị nlereanya akara otu, mmebi ogo nketetrahydrocurcuminOtu 100 mg/kg dị ala karịa nke ndị na-ahụ maka ihe nlereanya, ọ dịghịkwa skaab na erythema a hụrụ na akpụkpọ ahụ, ọ bụ naanị ntakịrị pigmenti na ezigbo wrinkles ka a hụrụ.
3. The antioxidant
Tetrahydrocurcumin nwere ike ịbawanye ọkwa SOD, belata ọkwa LDH yana ịbawanye ọkwa GSH-PX na sel HaCaT.
Na-ekpochapụ DPPH free radicals
NketetrahydrocurcuminA na-eji 10, 50, 80, 100, 200, 400, 800, 1600 mee ihe n'otu n'otu, a na-agwakọta ihe ngwọta nke ọma na 0.1 mmol / L DPPH ngwọta na nha nke 1: 5. Mgbe mmeghachi omume na ụlọ okpomọkụ maka 30min, a na-ekpebi uru nnabata na 517nm. E gosipụtara nsonaazụ ya na foto a:
4. Na-egbochi mbufụt akpụkpọ
Nnyocha nyocha gosiri na a na-ahụ ọgwụgwọ ọnya nke ụmụ oke na-aga n'ihu ruo ụbọchị 14, mgbe a na-eji THC-SLNS gel mee ihe, ọnya na-agwọ ọrịa ọsọ na mmetụta nke THC na njikwa ziri ezi dị ngwa ngwa ma dị mma, usoro na-agbada bụ THC-SLNS gel. >
THC> njikwa dị mma.
N'okpuru ebe a bụ foto ndị nnọchianya nke ụdị òké ọnya ahụ a chụpụrụ na ihe ndekọ akụkọ ihe mere eme, A1 na A6 na-egosi akpụkpọ anụ nkịtị, A2 na A7 na-egosi THC SLN gel, A3 na A8 na-egosi njikwa dị mma, A4 na A9 na-egosi THC gel, na A5 na A10 na-egosi oghere siri ike. lipid nanoparticles (SLN), n'otu n'otu.
• Ngwa nkeTetrahydrocurcuminNa ịchọ mma
1.Skin elekọta ngwaahịa:
Ngwaahịa na-egbochi ịka nká:A na-eji ude na-egbochi ịka nká na serums iji nyere aka belata wrinkles na ahịrị dị mma ma melite ngbanwe akpụkpọ ahụ.
Ngwaahịa na-acha ọcha:Agbakwunyere na isi ọcha na ude iji nyere aka melite ụda akpụkpọ ahụ na ntụpọ na-enweghị isi.
2.Mgbochi mkpali ngwaahịa:
A na-eji ngwaahịa nlekọta anụ ahụ dị nro dị ka ihe na-edozi ahụ na imezi ude iji belata ọbara ọbara na mgbakasị ahụ.
Ngwaahịa 3.Cleaning:
Tinye na ndị na-ehicha ihe na ndị na-ekpo ọkụ iji nyere aka mee ka akpụkpọ ahụ dị ọcha ma nye uru antibacterial iji gbochie ihe otutu.
Ngwaahịa 4.Sunscreen:
Na-arụ ọrụ dị ka antioxidant iji welie ịdị irè nke mkpuchi anwụ ma chebe akpụkpọ ahụ pụọ na ụzarị UV.
5. Ihu nkpuchi:
A na-eji ihe mkpuchi ihu dị iche iche na-enye nri miri emi na nrụzi, na-eme ka akpụkpọ anụ dịkwuo mma.
Tetrahydrocurcumina na-ejikarị eme ihe na ịchọ mma, na-ekpuchi nlekọta anụ ahụ, ihicha, nchebe anyanwụ na ubi ndị ọzọ. A na-akwado ya maka antioxidant ya, mgbochi mkpali na ịcha ọcha.
Oge nzipu: Ọktoba 10-2024
