Nnyocha na-egosi na ihe dị ka nde ndị okenye 537 n'ụwa niile nwere ụdị ọrịa shuga 2, ọnụ ọgụgụ ahụ na-arị elu. Ọkwa shuga dị elu nke ọrịa shuga na-akpata nwere ike ibute ọtụtụ ọnọdụ dị ize ndụ, gụnyere ọrịa obi, ịhụhụ ụzọ, ọdịda akụrụ, na nsogbu ahụike ndị ọzọ. Ihe niile nwere ike ime ka ịka nká dịkwuo mma.
Tetrahydrocurcumin, nke sitere na mgbọrọgwụ turmeric, egosiwo na nchọpụta ụlọ ọgwụ iji nyere aka belata ọtụtụ ihe ize ndụ maka ụdị ọrịa shuga 2 na obere ọbara shuga na ndị nwere ọrịa shuga ma ọ bụ ọrịa shuga. Ịgwọ ụdị ọrịa shuga 2 nwere ike bụrụ ihe ịma aka maka ma ndị ọrịa ma ndị dọkịta. Ọ bụ ezie na ndị dọkịta na-akwadokarị nri, mmega ahụ, na ọgwụ iji gwọọ ndị nwere ụdị ọrịa shuga 2, nchọpụta na-egosi natetrahydrocurcuminnwere ike inye nkwado ọzọ.
• Nguzogide insulin na ọrịa shuga
Mgbe anyị na-eri nri, shuga ọbara anyị na-ebili. Nke a na-egosi na pancreas na-ewepụta homonụ a na-akpọ insulin, nke na-enyere mkpụrụ ndụ aka iji glucose na-emepụta ike. N'ihi ya, shuga ọbara na-agbada ọzọ. Ụdị ọrịa shuga 2dị nke Abụọ bụ nguzogide insulin n'ihi na mkpụrụ ndụ anaghị anabata nke ọma na homonụ. Ọkwa shuga dị n'ọbara ka na-abawanye, ọnọdụ a na-akpọ hyperglycemia. Ọbara shuga dị elu nwere ike ibute nsogbu sistemu, gụnyere obi, arịa ọbara, akụrụ, anya, na nsogbu sistem ụjọ, yana ịbawanye ohere nke ọrịa kansa.
Mbufụt nwere ike itinye aka na nguzogide insulin ma mee ka hyperglycemia dịkwuo njọ na ndị nwere ọrịa shuga. [8,9] Ọbara shuga dị elu na-ebute mbufụt, nke na-eme ka ịka nká dịkwuo elu ma na-abawanye ohere nke ọrịa na-adịghị ala ala, dị ka ọrịa obi na ọrịa kansa. Oke glucose na-ebutekwa nrụgide oxidative, nke nwere ike imebi mkpụrụ ndụ na anụ ahụ nke ukwuu. N'ime nsogbu ndị ọzọ, nrụgide oxidative nwere ike ibute:mbelata ibufe glucose na insulin secretion, protein na DNA mebiri emebi, yana mmụba nke akwara vaskụla.
• Gịnị bụ uru nkeTetrahydrocurcuminNa ọrịa shuga?
Dị ka ihe na-arụ ọrụ na turmeric,Tetrahydrocurcuminnwere ike inye aka gbochie mmepe nke ọrịa shuga yana mmebi ọ nwere ike ịkpata n'ọtụtụ ụzọ, gụnyere:
1. Ịrụ ọrụ nke PPAR-γ, nke bụ onye na-achịkwa metabolism nke na-eme ka mmetụta insulin dịkwuo elu ma na-ebelata nkwụsị insulin.
2. Mmetụta mgbochi mkpali, gụnyere mgbochi nke ụmụ irighiri ihe na-eme ka ọ dịkwuo ọkụ.
3. Mmalite ọrụ na ahụike nke cell na-ezobe insulin.
4. Mbelata mmepụta nke ngwaahịa njedebe glycation dị elu ma gbochie mmebi ha na-akpata.
5. Ọrụ antioxidant, nke na-ebelata nrụgide oxidative.
6. Profaịlụ lipid kwalitere ma belata ụfọdụ akara nke dysfunction metabolic na ọrịa obi.
N'ụdị anụmanụ,tetrahydrocurcumingosipụtara nkwa na-enyere aka igbochi mmepe nke ọrịa shuga yana ibelata nguzogide insulin.
• Gịnị bụ uru nkeTetrahydrocurcuminNa Cardiovascular?
Nnyocha 2012 e bipụtara na International Journal of Pharmacology tụlere mmetụta nketetrahydrocurcuminna mgbanaka aortic òké iji hụ ma ogige ahụ nwere akụrụngwa cardioprotective. Nke mbụ, ndị na-eme nchọpụta gbasaa mgbanaka aortic na carbachol, nke a maara maka ịkpata vasodilation. Mgbe ahụ, a gbanyere ụmụ oke ahụ na homocysteine thiolactone (HTL) iji gbochie vasodilation. [16] N'ikpeazụ, ndị nchọpụta ahụ gbanyere ụmụ oke na 10 μM ma ọ bụ 30 μM nke.tetrahydrocurcuminwee chọpụta na ọ kpalitere vasodilation na ọkwa dịka carachol.
Dị ka ọmụmụ a si kwuo, HTL na-emepụta vasoconstriction site n'ibelata ọnụọgụ nitric oxide na arịa ọbara na ịbawanye mmepụta nke free radicals. Ya mere,tetrahydrocurcuminga-emetụta mmepụta nke nitric oxide na / ma ọ bụ free radicals iji weghachi vasodilation. Ebe ọ bụ natetrahydrocurcuminnwere mmetụta antioxidant siri ike, ọ nwere ike mebie radicals free.
• Gịnị bụ uru nkeTetrahydrocurcuminNa ọbara mgbali elu?
Ọ bụ ezie na ọbara mgbali elu nwere ike ịkpata ihe dị iche iche, ọ na-abụkarị n'ihi njide arịa ọbara gabigara ókè, nke na-eduga ná mbelata nke arịa ọbara.
N'ime nnyocha 2011, ndị nchọpụta nyeretetrahydrocurcuminiji hụ ka o siri metụta ọbara mgbali elu. Iji kpalite dysfunction vaskụla, ndị nchọpụta ahụ jiri L-arginine methyl ester (L-NAME). E kewara ụmụ oke ahụ ụzọ atọ. Otu nke mbụ natara L-NAME, nke abụọ natara tetrahydrocurcumin (50mg/kg arọ ahụ) na L-NAME, na otu nke atọ natara.tetrahydrocurcumin(100mg/kg arọ ahụ) na L-NAME.
Mgbe izu atọ nke doses kwa ụbọchị, natetrahydrocurcuminotu gosipụtara mbelata ọbara mgbali elu ma e jiri ya tụnyere otu ndị were naanị L-NAME. Otu e nyere ọgwụ dị elu nwere mmetụta dị mma karịa otu e nyere obere dose. Ndị nchọpụta ahụ kwuru na ọ bụ nsonaazụ ọmatetrahydrocurcuminike na-akpali vasodilation.
Oge nzipu: Ọktoba 10-2024
