• Gịnị BụLycopene ?
Lycopene bụ carotenoid eke, nke a na-ahụkarị na mkpụrụ osisi na akwụkwọ nri dịka tomato. Ọdịdị kemịkal ya nwere njikọ abụọ jikọtara ọnụ 11 yana njikọ abụọ na-enweghị njikọ, ma nwee ọrụ antioxidant siri ike.
Lycopene nwere ike ichekwa spam na ROS, si otú ahụ na-eme ka sperm motility dịkwuo mma, na-egbochi prostate hyperplasia, prostate cancer cell carcinogenesis, ibelata ọrịa imeju abụba abụba, atherosclerosis na ọrịa obi obi, na-eme ka nchebe mmadụ dịkwuo mma, na ibelata mmebi akpụkpọ ahụ nke ìhè ultraviolet kpatara.
Ahụ mmadụ enweghị ike ịmepụta lycopene n'onwe ya, a na-esikwa ya nweta ya naanị site na nri. Mgbe absorption gasịrị, a na-echekwa ya na imeju. Enwere ike ịhụ ya na plasma, seminal vesicles, prostate na anụ ahụ ndị ọzọ.
• Gịnị bụ uru nkeLycopeneMaka Nkwadebe Ime Ime Nwoke?
Mgbe arụ ọrụ RAGE gasịrị, ọ nwere ike ime ka mmeghachi omume sel na-eduga na mmepụta nke ROS, si otú ahụ na-emetụta ọrụ spam. Dị ka antioxidant siri ike, lycopene nwere ike imenyụ oxygen singlet, wepụ ROS, ma gbochie sperm lipoproteins na DNA ịbụ oxidized. Nnyocha egosiwo na lycopene nwere ike ibelata ọkwa nke nnabata maka ngwaahịa njedebe glycation dị elu (RAGE) n'ime ọbara mmadụ, si otú a na-eme ka mmịpụta spam na-eme ka ọ dịkwuo mma.
Ọdịnaya Lycopene dị elu na mpi ụmụ nwoke nwere ahụike, mana ọ dị ala na ụmụ nwoke na-amụghị nwa. Nnyocha ụlọ ọgwụ achọpụtala na lycopene nwere ike imeziwanye ogo spam nwoke. A gwara ndị ikom na-amụghị nwa dị afọ 23 ruo 45 ka ha na-aṅụ lycopene ọnụ ugboro abụọ n'ụbọchị. Ọnwa isii ka e mesịrị, a na-enyochakwa itinye uche sperm ha, ọrụ ha na ọdịdị ha. Otu ụzọ n'ụzọ anọ nke ndị ikom emeela ka mmụba nke mmịpụta na morphology dị mma nke ukwuu, na ntinye nke spam na-eme ka ọ dịkwuo mma.
• Gịnị bụ uru nkeLycopeneMaka nwoke prostate?
1. Prostate Hyperplasia
Prostatic hyperplasia bụ ọrịa a na-ahụkarị na ụmụ nwoke, na n'afọ ndị na-adịbeghị anya, ọnụ ọgụgụ ya na-ebelata nke ukwuu. Mgbaàmà nke usoro urinary ala (ngwa ngwa mmamịrị / urination ugboro ugboro / urination ezughị ezu) bụ isi ngosipụta nke ụlọ ọgwụ, nke na-emetụta oke ndụ ndụ ndị ọrịa.
Lycopenenwere ike igbochi mgbasa nke sel prostate epithelial prostate, kwalite apoptosis na prostate anụ ahụ, kpalie intercellular gap junction nkwurịta okwu iji gbochie cell nkewa, na n'ụzọ dị irè belata ọkwa nke mkpali ihe dị ka interleukin IL-1, IL-6, IL-8 na tumor necrosis. ihe (TNF-α) iji mee ihe mgbochi mkpali.
Nnwale ụlọ ọgwụ achọpụtala na lycopene nwere ike imeziwanye hyperplasia prostate na eriri afo na-arụ ọrụ eriri akwara dị nro na ndị buru oke ibu ma na-ebelata mgbaàmà nke eriri afọ urinary dị ala. Lycopene nwere mmetụta ọgwụgwọ dị mma na mmekwata nke ọma na mgbaàmà urinary tract dị ala nke prostate hypertrophy na hyperplasia kpatara, nke metụtara antioxidant siri ike na mgbochi mkpali nke lycopene.
2. Ọrịa kansa prostate
Enwere ọtụtụ akwụkwọ ahụike na-akwado nke ahụlycopenena nri kwa ụbọchị na-ekere òkè dị mkpa n'igbochi ọrịa cancer prostate, na oriri nke lycopene na-ejikọta ya na ihe ize ndụ nke ọrịa cancer prostate. Ekwenyere na usoro ya nwere njikọ na-emetụta okwu nke mkpụrụ ndụ ihe nketa na protein ndị metụtara tumor, na-egbochi mgbasa mkpụrụ ndụ cancer na nrapanye, na ịkwalite nkwurịta okwu intercellular.
Nnwale na mmetụta nke lycopene na ọnụọgụ ndụ nke mkpụrụ ndụ kansa prostate mmadụ: N'ime nyocha ahụike ahụike, ejiri lycopene na-agwọ ahịrị mkpụrụ ndụ cancer prostate mmadụ DU-145 na LNCaP.
Nsonaazụ gosiri nalycopenenwere mmetụta mgbochi dị ịrịba ama na mmụba nke mkpụrụ ndụ DU-145, a na-ahụkwa mmetụta mgbochi na 8μmol / L. Mmetụta mgbochi nke lycopene na ya nwere njikọ chiri anya na dose ahụ, na oke mgbochi nwere ike iru 78%. N'otu oge ahụ, ọ nwere ike igbochi mmụba nke LNCaP, yana enwere mmekọrịta doro anya na mmetụta dose. Ọnụego mgbochi kachasị na ọkwa 40μmol / L nwere ike iru 90%.
Nsonaazụ gosiri na lycopene nwere ike igbochi mmụba nke mkpụrụ ndụ prostate ma belata ohere nke mkpụrụ ndụ cancer prostate ịghọ ọrịa kansa.
Oge nzipu: Nov-20-2024
