N'afọ adịbeghị anya,NMN, bụ nke na-ewu ewu n'ụwa nile, ejirila ọtụtụ nyocha na-ekpo ọkụ. Kedu ihe ị maara maka NMN? Taa, anyị ga-elekwasị anya na iwebata NMN, nke onye ọ bụla hụrụ n'anya.
● Gịnị bụNMN?
A na-akpọ NMN β-Nicotinamide Mononucleotide, ma ọ bụ NMN maka mkpụmkpụ. NMN nwere diastereomers abụọ: α na β. Nnyocha achọpụtala na naanị β-ụdị NMN nwere ọrụ ndu. N'usoro, ihe mejupụtara molekul ahụ bụ nicotinamide, ribose, na phosphate.
NMN bụ otu n'ime ihe mmalite nke NAD +. N'ikwu ya n'ụzọ ọzọ, a na-enweta isi mmetụta nke NMN site na ntụgharị na NAD +. Ka anyị na-aka nká, ọkwa NAD+ n'ahụ mmadụ na-eji nwayọọ nwayọọ na-ebelata.
Na 2018 Aging Biology Research Compilation, a chịkọtara usoro abụọ bụ isi nke ịka nká mmadụ:
1. Mmebi kpatara nrụgide oxidative (akara ngosi gosipụtara dị ka ọrịa dị iche iche)
2. Mbelata ọkwa nke NAD + na sel
Ọnụ ọgụgụ dị ukwuu nke agụmakwụkwọ na nchọpụta NAD + mgbochi ịka nká site n'aka ndị ọkà mmụta sayensị kachasị elu n'ụwa kwadoro nkwubi okwu na ịba ụba NAD + nwere ike ime ka ogo ahụike dịkwuo mma n'ọtụtụ akụkụ na igbu oge ịka nká.
● Kedu ihe bụ uru ahụikeNMN?
1.Na-abawanye ọdịnaya NAD +
NAD + bụ ihe dị mkpa maka ịnọgide na-arụ ọrụ nke ahụ. Ọ dị na sel niile ma na-ekere òkè na ọtụtụ puku mmeghachi omume physiological n'ime ahụ. Ihe karịrị 500 enzymes na ahụ mmadụ chọrọ NAD +.
Site na ọnụ ọgụgụ ahụ, anyị nwere ike ịhụ na uru dị n'itinye NAD + na akụkụ dị iche iche gụnyere imezi ahụike nke ụbụrụ na sistem ụjọ, imeju na akụrụ, arịa ọbara, obi, anụ ahụ lymphatic, akụkụ ọmụmụ, pancreas, anụ ahụ adipose, na akwara.
Na 2013, otu ndị nyocha nke Prọfesọ David Sinclair nke Harvard Medical School duziri site na nnwale na mgbe nchịkwa ọnụ nke NMN otu izu gasịrị, ọkwa NAD + na ụmụ oke dị ọnwa 22 mụbara, yana isi ihe na-egosi biochemical metụtara mitochondrial homeostasis na eweghachitere ọrụ akwara na ọnọdụ ụmụ oke ụmụ oke ruru ọnwa isii.
2. Mee ka protein SIR rụọ ọrụ
Nnyocha n'ime afọ 20 gara aga achọpụtala na Sirtuins na-arụ ọrụ nchịkwa dị ukwuu n'ihe fọrọ nke nta ka ọ bụrụ ọrụ cell niile, na-emetụta usoro physiological dị ka mbufụt, uto cell, circadian rhythm, ume metabolism, ọrụ neuronal na nrụgide nrụgide.
A na-akpọkarị Sirtuins dị ka ezinụlọ protein ogologo ndụ, nke bụ ezinụlọ nke NAD + dabere na protein deacetylase.
Na 2019, Prọfesọ Kane AE nke Ngalaba Genetics na Harvard Medical School na ndị ọzọ chọpụtara nke ahụNMNbụ ihe dị mkpa maka njikọ nke NAD + n'ime ahụ. Mgbe NMN na-abawanye ọkwa nke NAD + n'ime sel, ọtụtụ n'ime mmetụta bara uru (dị ka imeziwanye metabolism, na-echebe usoro obi, wdg) na-enweta site na ịgbalite Sirtuins.
3. Dozie mmebi DNA
na mgbakwunye na imetụta ọrụ nke Sirtuins, ọkwa NAD + n'ime ahụ bụkwa ihe dị mkpa maka DNA mmezi enzyme PARPs (poly ADP-ribose polymerase).
4. Na-akwalite metabolism
Metabolism bụ nchịkọta mmeghachi omume kemịkalụ na-edobe ndụ n'ime ihe ndị dị ndụ, na-enye ha ohere itolite na ịmụpụta, na-edobe nhazi ha, na imeghachi omume na gburugburu ebe obibi. Metabolism bụ usoro nke ntule na-aga n'ihu na-agbanwe ihe na ume. Ozugbo ọ kwụsịrị, ndụ nke organism ga-akwụsị. Prọfesọ Anthony nke Mahadum California na ndị otu ya chọpụtara na NAD + metabolism aghọwo ọgwụgwọ nwere ike ime ka ọrịa ndị metụtara ịka nká dịkwuo mma na ịgbatị ahụike na ndụ mmadụ.
5. Kwalite mmụba arịa ọbara ma nọgide na-agbatị arịa ọbara
Ụgbọ mmiri bụ anụ ahụ dị mkpa maka ibuga oxygen na nri nri, nhazi carbon dioxide na metabolites, na ịhazi okpomọkụ ahụ. Ka anyị na-akawanye nká, arịa ọbara ji nwayọọ nwayọọ na-efunahụ mgbanwe ha, na-esi ike, dị arọ, na warara, na-akpata "arteriosclerosis."
Na 2020, nnyocha ụfọdụ ụmụ akwụkwọ PhD sitere na Mahadum Teknụzụ nke Zhejiang dị na China, gụnyere Sh, chọpụtara na mgbe nchịkwa ọnụ gasịrị.NMNna ụmụ oke dara mbà n'obi, a na-ebelata ihe mgbaàmà nke ịda mbà n'obi site na ịba ụba NAD +, na-eme ka Sirtuin 3 rụọ ọrụ, na imeziwanye metabolism ike mitochondrial na hippocampus na mkpụrụ ndụ imeju nke ụbụrụ ụmụ oke.
6. Chebe ahụike obi
Obi bụ akụkụ kacha mkpa na ahụ mmadụ ma dị mkpa maka ịnọgide na-arụ ọrụ obi. Mbelata nke ọkwa NAD + metụtara pathogenesis nke ọrịa obi dị iche iche. Ọnụ ọgụgụ dị ukwuu nke nchọpụta bụ isi egosiwokwa na mgbakwunye coenzyme m nwere ike irite uru ụdị ọrịa obi.
7. Na-edobe ahụike ụbụrụ
Ịrụ ọrụ akwara ozi nwere ike ime ka vaskụla mmalite na mmebi nke ụbụrụ neurodegenerative mebie. Ịnọgide na-arụ ọrụ akwara ozi dị mkpa maka igbochi ọrịa neurodegenerative.
Ihe ize ndụ dị ka ọrịa shuga, ọbara mgbali elu etiti ndụ, oke ibu nke etiti ndụ, adịghị arụ ọrụ anụ ahụ na ise siga na-ejikọta ya na dementia vaskụla na ọrịa Alzheimer.
8. Meziwanye mmetụta insulin
Mmetụta insulin na-akọwa ogo nguzogide insulin. Na-ebelata mmetụta insulin, na-ebelata ogo ndakpọ shuga.
Nguzogide insulin na-ezo aka na mbelata uche nke akụkụ ebumnuche insulin na-arụ ọrụ nke insulin, ya bụ, ọnọdụ nke ọgwụ insulin nkịtị na-emepụta mmetụta dị ala karịa nkịtị. Isi ihe na-akpata ọrịa shuga 2dị nke abụọ bụ ụkọ insulin na-enwechaghị mmetụta na mmetụta insulin.
NMN, dị ka ihe mgbakwunye, nwere ike inye aka melite mmetụta insulin site n'ịbawanye ọkwa NAD +, na-achịkwa ụzọ metabolic, na imeziwanye ọrụ mitochondrial.
9. Enyemaka na njikwa ibu
Ibu ibu abụghị nanị na-emetụta àgwà ndụ na ahụike, kamakwa ọ na-aghọ ihe na-akpalite ọrịa ndị ọzọ na-adịghị ala ala. Nnyocha egosiwo na NAD precursor β-nicotinamide mononucleotide (NMN) nwere ike gbanwee ụfọdụ mmetụta ọjọọ nke nri nwere oke abụba (HFD).
Na 2017, Prọfesọ David Sinclair nke Harvard Medical School na otu ndị nyocha sitere na ụlọ akwụkwọ ahụike Australia tụlere ụmụ oke oke ibu bụ ndị na-emega ahụ n'obere igwe maka izu 9 ma ọ bụ na-agbanye NMN kwa ụbọchị maka ụbọchị iri na asatọ. Nsonaazụ gosiri na NMN yiri ka ọ na-enwe mmetụta siri ike na abụba imeju metabolism na njikọ karịa mgbatị ahụ.
● Nchekwa nkeNMN
A na-ewere NMN dị mma na nnwale anụmanụ, nsonaazụ ya na-agba ume. Ngụkọta nke nnwale ụlọ ọgwụ mmadụ 19 amalitela, nke 2 ebipụtala nsonaazụ nnwale.
Otu nnyocha sitere na Ụlọ Akwụkwọ Ọgwụ na Mahadum Washington dị na St Louis bipụtara otu isiokwu na akwụkwọ akụkọ sayensị kachasị elu "Science", na-ekpughe nsonaazụ nke ule mbụ nke ụlọ ọgwụ mmadụ n'ụwa, na-akwado uru metabolic nke NMN na ahụ mmadụ.
●NEWGREEN na-eweta NMN ntụ ntụ/capsules/Liposomal NMN
Oge nzipu: Ọktoba 15-2024
