Berberine : nkeji ise ka ị mụta maka uru ahụike ya

● Olee uru Berberine bara n’ahụ́ ike?

1.Antioxidant

N'okpuru ọnọdụ nkịtị, ahụ mmadụ na-edobe nguzozi n'etiti antioxidants na prooxidants. Nchegbu oxidative bụ usoro na-emerụ ahụ nke nwere ike ịbụ onye ogbugbo dị mkpa nke mmebi ihe owuwu cell, si otú ahụ na-ebute ọrịa dị iche iche dị ka ọrịa obi, ọrịa cancer, ọrịa akwara ozi na ọrịa shuga. Mmepụta oke ikuku oxygen na-emeghachi omume (ROS), nke a na-ejikarị site na mkpali NADPH gabigara ókè site na cytokines ma ọ bụ site na mitochondrial eletrọn transport chain na xanthine oxidase, nwere ike ibute nrụgide oxidative. Nnwale egosiwo na berberine metabolites na berberine na-egosi ọrụ scavenging -OH magburu onwe ya, nke bụ ihe dị ka vitamin C antioxidant siri ike. nchịkwa nke berberine na oke ndị na-arịa ọrịa shuga nwere ike nyochaa mmụba nke SOD (superoxide dismutase) ọrụ na mbelata na MDA (a) akara nke lipid peroxidation) ọkwa [1]. Nsonaazụ ndị ọzọ na-egosi na ọrụ scavenging nke berberine nwere njikọ chiri anya na ọrụ ferrous ion chelating ya, yana otu C-9 hydroxyl nke berberine bụ akụkụ dị mkpa.

2.Mgbochi tumor

Enweela ọtụtụ akụkọ banyere mmetụta mgbochi ọrịa cancer nkeberberine. Nnyocha dị iche iche n'afọ ndị na-adịbeghị anya egosila na berberine dị oke mkpa na ọgwụgwọ adjuvant nke ọrịa cancer siri ike dị ka ọrịa cancer ovarian, ọrịa cancer endometrial, cancer cervical, cancer ara ara, cancer akpa ume, cancer colorectal, cancer akụrụ, cancer eriri afo, na prostate cancer. [2]. Berberine nwere ike igbochi mmụba nke mkpụrụ ndụ etuto site na iji ebumnuche na usoro dị iche iche na-emekọrịta ihe. Ọ nwere ike ịgbanwe okwu nke oncogenes na mkpụrụ ndụ ihe nketa carcinogenesis iji nweta nzube nke ịchịkwa ọrụ nke enzymes metụtara iji gbochie mgbasa.

3.Iwedata lipids ọbara na ichekwa sistemu obi

Berberine na-arụ ọrụ dị mkpa na ọgwụgwọ ọrịa obi ma nwee ọtụtụ ngwa. Berberine na-enweta ebumnobi nke mgbochi arrhythmia site n'ibelata ihe omume nke ịkụ aka akaghi aka ventricular na igbochi omume tachycardia ventricular. Nke abuo, dyslipidemia bụ isi ihe kpatara ọrịa obi, nke a na-eji ọkwa cholesterol zuru oke, triglycerides, na obere njupụta lipoprotein cholesterol (LDL), yana mbelata nke lipoprotein dị elu (HDL), na berberine nwere ike ịnọgide na-enwe ahụ ike. nkwụsi ike nke ihe ngosi ndị a. Hyperlipidemia na-adịte aka bụ ihe dị mkpa na-akpata mkpụpụta atherosclerotic plaque. A na-akọ na berberine na-emetụta ndị na-anabata LDL na hepatocytes iji belata ọkwa cholesterol ọbara mmadụ na hepatocytes. Ọ bụghị naanị nke ahụ,berberinenwere mmetụta inotropic dị mma ma jiri ya na-agwọ nkụchi obi.

4. Na-ebelata shuga ọbara ma na-achịkwa Endocrine

Ọrịa shuga mellitus (DM) bụ ọrịa metabolic na-egosi mmụba shuga dị n'ọbara (hyperglycemia) nke enweghị ike mkpụrụ ndụ B nke pancreatic imepụta insulin zuru oke, ma ọ bụ enweghị nzaghachi anụ ahụ dị mma maka insulin. Achọpụtara mmetụta hypoglycemic nke berberine na mberede n'afọ ndị 1980 na ọgwụgwọ ndị ọrịa nwere afọ ọsịsa.

Ọtụtụ nnyocha gosiri naberberinena-ebelata shuga ọbara site na usoro ndị a:

● Na-egbochi mitochondrial glucose oxidation ma na-akpali glycolysis, emesia na-abawanye glucose metabolism;
● Na-ebelata ọkwa ATP site na igbochi ọrụ mitochondrial na imeju;
● Na-egbochi ọrụ DPP 4 (protease serine a na-ahụkarị), si otú ahụ na-agbaji ụfọdụ peptides na-eme ka ọkwa insulin dịkwuo elu n'ihu hyperglycemia.
● Berberine nwere mmetụta bara uru n'ịkwalite nguzogide insulin na itinye glucose n'ọrụ n'anụ ahụ site n'ibelata lipids (karịsịa triglycerides) na ọkwa abụba na-enweghị plasma.

Nchịkọta

Ugbua,berberineenwere ike megharia ya site n'usoro injinia kristal. Ọ nwere ọnụ ala dị ala yana teknụzụ dị elu. Site na mmepe nke nyocha ahụike yana omimi nke nyocha kemịkalụ, berberine ga-egosipụta n'ezie mmetụta ọgwụ karịa. N'otu aka ahụ, berberine enwetabeghị nsonaazụ dị ịrịba ama na nyocha ọgwụ ọdịnala na antibacterial, antiviral, anti-inflammatory, anti-tumor, antidiabetic, na ọgwụgwọ nke ọrịa obi na cerebrovascular, kamakwa ya kristal engineering design na morphological analysis. enwetawo nlebara anya nke ukwuu. N'ihi ịdị irè ya dị ịrịba ama na obere nsị na mmetụta dị n'akụkụ, ọ nwere ikike dị ukwuu na ngwa ụlọ ọgwụ ma nwee atụmanya sara mbara. Site na mmepe nke bayoloji cell, a ga-akọwapụta usoro ọgwụ ọgwụ nke berberine site na ọkwa cellular na ọbụna ọkwa molecular na nke ebumnuche, na-enye ihe ndabere maka usoro ọgwụgwọ ya.

● Enyemaka ỌhụrụBerberine/Liposomal Berberine ntụ ntụ / Capsules / mbadamba