N-Acetylneuraminic acid ntụ ntụ Onye nrụpụta Newgreen N-Acetylneuraminic acid Mgbakwunye
Nkọwa ngwaahịa
N-acetylneuraminic acid (NANA, Neu5Ac) bụ akụkụ bụ isi nke glycoconjugates, dị ka glycolipids, glycoproteins, na proteoglycans (sialoglycoproteins), nke na-enye njirimara nke nhọrọ ejikọta nke glycosylated components. A na-eji Neu5Ac mụọ biochemistry ya, metabolism na nnabata na vivo na in vitro. Enwere ike iji Neu5Ac na mmepe nke nanocarriers.
COA
| Ihe | Nkọwapụta | Nsonaazụ | |
| Ọdịdị | Ọcha ntụ ntụ | Ọcha ntụ ntụ | |
| Nyocha |
| Gafe | |
| Isi | Ọ dịghị | Ọ dịghị | |
| Njupụta dị larịị (g/ml) | ≥0.2 | 0.26 | |
| Ọnwụ na ihicha | ≤8.0% | 4.51% | |
| Ihe fọdụrụ na mgbanye | ≤2.0% | 0.32% | |
| PH | 5.0-7.5 | 6.3 | |
| Nkezi ịdị arọ molekụla | <1000 | 890 | |
| Ọla dị arọ (Pb) | ≤1PPM | Gafe | |
| As | ≤0.5PPM | Gafe | |
| Hg | ≤1PPM | Gafe | |
| Ọnụọgụ nje | ≤1000cfu/g | Gafe | |
| Colon Bacillus | ≤30MPN/100g | Gafe | |
| Yist & ebu | ≤50cfu/g | Gafe | |
| Ọrịa nje pathogenic | Ihe ọjọọ | Ihe ọjọọ | |
| Mmechi | Dakọtara na nkọwapụta | ||
| Ndụ nchekwa | Afọ 2 mgbe echekwara nke ọma | ||
Ọrụ
1. Melite ọgụgụ isi na ebe nchekwa nwa
N-Acetylneuraminic acid bụ ihe dị mkpa na-ewu ụlọ gangliosides na ụbụrụ. Ọdịnaya nke sialic acid dị na akpụkpọ ahụ cell akwara ji okpukpu 20 karịa nke sel ndị ọzọ. N'ihi na nnyefe nke ozi ụbụrụ na nduzi nke mkpali akwara ga-emerịrị site na synapses, na N-Acetylneuraminic acid bụ ụbụrụ ụbụrụ nke na-arụ ọrụ na ụbụrụ cell membranes na synapses, ya mere N-Acetylneuraminic acid nwere ike ịkwalite mmepe nke ebe nchekwa na ọgụgụ isi. Nnyocha achọpụtala na ịba ụba ọdịnaya nke N-Acetylneuraminic acid na nri inye nwa ara ga-abawanye ọdịnaya nke N-Acetylneuraminic acid na ụbụrụ nwa ọhụrụ, na ọkwa ọkwa nke mkpụrụ ndụ ihe nketa metụtara mmụta ga-abawanye, si otú ahụ na-eme ka ikike mmụta na ikike icheta dịkwuo elu. N'ime ụmụ ọhụrụ, ọdịnaya nke N-Acetylneuraminic acid bụ naanị 25% nke na mmiri ara ara.
2. Anti-senile dementia
N-Acetylneuramine acid nwere mmetụta nchebe na nkwụsi ike na mkpụrụ ndụ akwara. Mgbe protease dị n'elu akpụkpọ ahụ akwara jikọtara ya na N-Acetylneuraminic acid, ọ nweghị ike imebi ya site na extracellular protease. Ụfọdụ ọrịa akwara ozi, dị ka mgbaka agadi na schizophrenia, ga-ebelata ọdịnaya N-Acetylneuraminic acid n'ime ọbara ma ọ bụ ụbụrụ, na mgbe mgbake site na ọgwụgwọ ọgwụ, ọdịnaya N-Acetylneuraminic acid ga-alaghachi na nkịtị, nke na-egosi na N-Acetylneuraminic acid na-ekere òkè. na usoro metabolic nke mkpụrụ ndụ akwara.
3. Mgbochi nnabata
N'etiti ụmụ irighiri ihe na mkpụrụ ndụ, n'etiti sel na sel, na n'etiti sel na ụwa dị n'èzí, N-Acetylneuraminic acid na njedebe nke agbụ shuga nwere ike ịbụ ebe a na-amata ma ọ bụ kpuchie ebe a na-amata. N-Acetylneuraminic acid jikọtara na njedebe nke glycosides site na njikọ glycosidic nwere ike igbochi ụfọdụ saịtị antigenic dị mkpa na akara njirimara na elu cell, si otú ahụ na-echebe ndị saccharide ndị a ka a ghara ịmata ma mebie ya site na usoro nchebe gburugburu.
Ngwa
1. A na-eji N-Acetylneuraminic acid na-emepụta ihe dị iche iche nke neuraminidase inhibitors, glycolipids na ihe ndị ọzọ na-emepụta ihe na-emepụta ihe. Enwere ike iji ya mee ihe mgbakwunye nri.
2. N-Acetylneuraminic acid na-arụ ọrụ dị mkpa na mgbakwunye nri dị ka glyconutrient. Ọ na-achịkwa protein ọbara ọkara ndụ, acidification, neutralization nke dị iche iche nsị, cell adhesion na glycoprotein lysis nchebe. Enwere ike iji dị ka ihe mgbakwunye nri.
3. N-Acetylneuramine acid nwere ike ji mee ihe dị ka a mmalite reagent maka njikọ nke biochemical mmepụta nke ọgwụ ọjọọ. Enwere ike iji ya mee ihe ịchọ mma.
Ngwungwu & Nbunye
