Terbinafine Hydrochloride High Purity API Khoom CAS 78628-80-5
Product Description
Terbinafine Hydrochlorideyog ib qho tshuaj tua kab mob siv los kho ntau yam kab mob. Nws yog feem ntau nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj los yog cream. terbinafine hydrochloride yog ib qho tshuaj tua kab mob zoo siv los kho ntau yam kab mob fungal. Txawm hais tias nws hais txog tus neeg ncaws pob ko taw lossis cov kab mob fungal, cov tshuaj no ua haujlwm los ntawm kev cuam tshuam ergosterol ntau lawm thiab muaj ob qho tib si tshuaj pleev ib ce thiab qhov ncauj kev xaiv rau kev yooj yim thiab ua tau zoo.
COA
| Yam khoom | STANDARD | TEST RESULT |
| Assay | 99% | Ua raws |
| Xim | Dawb hmoov | Ua raws |
| tsw | Tsis muaj ntxhiab tsw tshwj xeeb | Ua raws |
| Particle loj | 100% dhau 80 mesh | Ua raws |
| Poob rau ziab | ≤ 5.0% | 2.35% |
| Cov seem | ≤ 1.0% | Ua raws |
| Hnyav hlau | ≤ 10.0ppm | 7ppm ua |
| As | ≤ 2.0ppm | Ua raws |
| Pb | ≤ 2.0ppm | Ua raws |
| Tshuaj tua kab residue | Tsis zoo | Tsis zoo |
| Tag nrho cov phaj suav | ≤100cfu / g | Ua raws |
| Poov & Pwm | ≤100cfu / g | Ua raws |
| E. Coli | Tsis zoo | Tsis zoo |
| Salmonella | Tsis zoo | Tsis zoo |
| Xaus | Raws li Specification | |
| Cia | Khaws rau hauv qhov chaw txias & qhuav, Cia kom deb ntawm lub teeb muaj zog thiab cua sov | |
| Txee lub neej | 2 xyoos thaum khaws cia zoo | |
Muaj nuj nqi
1.Terbinafine hydrochloride ib qho hluavtaws allyla antifungal. Nws yog lipophilic heev nyob rau hauv cov xwm thiab nyhav rau hauv daim tawv nqaij, rau tes, thiab cov ntaub so ntswg rog.
2.Terbinafine·HCl ib tug tswv cuab ntawm pawg allyl ntawm cov tshuaj tua kab mob, tau pom tias yog ib qho tshwj xeeb inhibitor ntawm ergosterol synthesis ntawm squalene epoxidase inhibition. Squalene epoxidase yog ib qho enzyme tso tawm los ntawm cov kab mob dermatophyte kom zom Squalene, uas cuam tshuam nrog cell membrane ua haujlwm thiab phab ntsa synthesis.
3.Terbinafine hydrochloride muaj cov nyhuv fungicidal ntawm daim tawv nqaij fungi thiab inhibitory nyhuv ntawm Candida albicans. Nws yog qhov tsim nyog rau cov kab mob ntawm daim tawv nqaij thiab cov ntsia hlau uas tshwm sim los ntawm cov kab mob fungal, xws li kab mob ringworm, ringworm ntawm lub cev, ringworm ntawm femur, ringworm ntawm ko taw, ringworm ntawm tus ntsia thawv thiab Candida albicans kab mob ntawm daim tawv nqaij tshwm sim los ntawm Trichophyton rubrum, Microsporum canis. thiab Flocculus epidermidis.
Daim ntawv thov
Terbinafine hydrochloride yog dawb zoo crystalline hmoov uas yog dawb do soluble nyob rau hauv methan thiab dichlorome, soluble nyob rau hauv ethanol, thiab me ntsis soluble nyob rau hauv dej. Zoo li lwm yam allylamines, terbinafine inhibits ergosterol synthesis los ntawm inhibiting squalene epoxidase,
ib qho enzyme uas yog ib feem ntawm fungal cell membrane synthesis pathway. Vim tias terbinafine tiv thaiv kev hloov pauv ntawm squalene rau lanosterol, ergosterol tsis tuaj yeem ua ke. Qhov no yog xav kom hloov cell membrane permeability, ua rau fungal cell lysis.
1. Terbinafine Hcl yog tsuas yog siv tau rau cov dermatophyte pawg ntawm fungi.
2. Raws li 1% qab zib los yog hmoov, nws yog siv tshuaj pleev ib ce rau cov tawv nqaij kab mob xws li jock khaus (tinea cruris),
ncaws pob taw (tinea pedis), thiab lwm yam kab mob ringworm (tinea corporis). Terbinafine cream ua haujlwm li ntawm ib nrab ntawm lub sijhawm xav tau
los ntawm lwm yam antifungals.
3. Qhov ncauj 250mg ntsiav tshuaj feem ntau yog muab rau kev kho mob ntawm onychomycosis, ib tug fungal ntsia thawv kab mob, feem ntau yog ib tug dermatophyte.
los yog Candida hom. Cov kab mob ntawm tus ntsia thawv fungal yog nyob tob hauv qab tus ntsia thawv nyob rau hauv lub cuticle uas siv tshuaj pleev ib ce
tsis tuaj yeem nkag mus rau hauv cov nyiaj txaus. Cov ntsiav tshuaj yuav, tsis tshua muaj, ua rau hepatotoxicity, yog li cov neeg mob tau ceeb toom txog qhov no thiab
tej zaum yuav raug saib xyuas nrog rau kev kuaj lub siab ua haujlwm. Lwm txoj hauv kev rau kev tswj hwm qhov ncauj tau raug kawm.
4. Terbinafine tej zaum yuav induce los yog exacerbate subacute cutaneous lupus erythematosus. Cov neeg uas muaj lupus erythematosus yuav tsum
thawj zaug tham txog kev pheej hmoo nrog lawv tus kws kho mob ua ntej pib kho.
Yam khoom
Newgreen Hoobkas kuj muab Amino acids raws li hauv qab no:
Ntim & Xa
