Kev tshawb fawb qhia tau hais tias kwv yees li 537 lab tus neeg laus thoob ntiaj teb muaj ntshav qab zib hom 2, thiab tus lej ntawd tau nce. Cov ntshav qab zib ntau dhau los ntawm ntshav qab zib tuaj yeem ua rau muaj kev phom sij, suav nrog kab mob plawv, tsis pom kev, lub raum tsis ua haujlwm, thiab lwm yam teeb meem kev noj qab haus huv loj. Tag nrho cov no tuaj yeem ua rau kev laus sai heev.
Tetrahydrocurcumin, muab los ntawm turmeric cag, tau pom nyob rau hauv kev tshawb fawb soj ntsuam los pab txo ntau yam kev pheej hmoo rau hom 2 mob ntshav qab zib thiab txo cov ntshav qab zib hauv cov neeg mob ntshav qab zib lossis prediabetes. Kev kho mob ntshav qab zib hom 2 tuaj yeem nyuaj rau cov neeg mob thiab kws kho mob. Thaum cov kws kho mob feem ntau pom zoo kom noj zaub mov, qoj ib ce, thiab tshuaj kho cov neeg mob ntshav qab zib hom 2, kev tshawb fawb qhia tiastetrahydrocurcumintuaj yeem muab kev txhawb nqa ntxiv.
• Insulin Resistance Thiab Ntshav Qab Zib
Thaum peb noj, peb cov ntshav qab zib nce. Qhov no qhia tau hais tias pancreas tso cov tshuaj hu ua insulin, uas pab cov cell siv cov piam thaj los tsim lub zog. Yog li ntawd, cov ntshav qab zib poob dua. Hom 2 mob ntshav qab zib mellitus yog tshwm sim los ntawm insulin tsis kam vim cov hlwb tsis teb rau cov tshuaj hormones. Cov piam thaj hauv cov ntshav tseem nce siab, ib qho mob hu ua hyperglycemia. Cov ntshav qab zib ntau ntau tuaj yeem ua rau muaj teeb meem hauv lub cev, suav nrog lub plawv, cov hlab ntsha, lub raum, qhov muag, thiab lub paj hlwb, thiab ua rau muaj kev pheej hmoo ntawm mob qog noj ntshav.
Kev mob tshwm sim tuaj yeem ua rau cov tshuaj insulin tsis kam thiab ua rau hyperglycemia hauv cov neeg mob ntshav qab zib. [8,9] Cov ntshav qab zib siab ua rau mob ntau dua, uas ua rau muaj kev laus zuj zus ntxiv thiab ua rau muaj kev pheej hmoo ntawm cov kab mob ntev, xws li kab mob plawv thiab mob qog noj ntshav. Cov piam thaj ntau dhau kuj ua rau muaj kev ntxhov siab oxidative, uas tuaj yeem ua rau cov hlwb thiab cov ntaub so ntswg puas. Ntawm lwm cov teeb meem, oxidative kev nyuaj siab tuaj yeem ua rau:Txo cov piam thaj thauj thiab insulin secretion, protein thiab DNA puas, thiab nce vascular permeability.
• Cov txiaj ntsig yog dab tsiTetrahydrocurcuminHauv Ntshav Qab Zib?
Raws li ib tug active ingredient nyob rau hauv turmeric,Tetrahydrocurcumintuaj yeem pab tiv thaiv kev txhim kho ntshav qab zib thiab kev puas tsuaj nws tuaj yeem ua rau ntau txoj hauv kev, suav nrog:
1. Kev ua kom muaj zog ntawm PPAR-γ, uas yog tus tswj hwm cov metabolism hauv kev ua kom cov tshuaj insulin rhiab heev thiab txo cov tshuaj insulin.
2. Anti-inflammatory teebmeem, nrog rau inhibition ntawm signaling molecules uas ua rau o.
3. Txhim kho kev ua haujlwm thiab kev noj qab haus huv ntawm insulin-secreting cell.
4. Txo qhov tsim ntawm qib siab glycation kawg cov khoom thiab tiv thaiv kev puas tsuaj lawv ua.
5. Antioxidant kev ua haujlwm, uas txo cov oxidative kev nyuaj siab.
6. Txhim kho lipid profile thiab txo qee cov cim ntawm metabolic dysfunction thiab kab mob plawv.
Hauv cov qauv tsiaj,tetrahydrocurcuminqhia tau hais tias kev cog lus hauv kev pab tiv thaiv kev txhim kho ntshav qab zib thiab txo qis insulin tsis kam.
• Cov txiaj ntsig yog dab tsiTetrahydrocurcuminHauv Cardiovascular?
Ib txoj kev tshawb fawb 2012 luam tawm nyob rau hauv International Journal of Pharmacology soj ntsuam cov teebmeem ntawmtetrahydrocurcuminntawm nas aortic rings kom pom tias cov compound muaj cardioprotective zog. Ua ntej, cov kws tshawb fawb dilated lub aortic rings nrog carbachol, ib tug compound paub rau inducing vasodilation. Tom qab ntawd, cov nas raug txhaj nrog homocysteine thiolactone (HTL) txhawm rau txhawm rau vasodilation. [16] Thaum kawg, cov kws tshawb fawb tau txhaj cov nas nrog 10 μM lossis 30 μM ntawmtetrahydrocurcuminthiab pom tias nws ua rau vasodilation ntawm qib zoo ib yam li carbachol.
Raws li txoj kev tshawb no, HTL tsim cov vasoconstriction los ntawm kev txo qis ntawm nitric oxide hauv cov hlab ntsha thiab ua rau muaj cov dawb radicals. Yog li ntawd,tetrahydrocurcuminyuav tsum cuam tshuam rau kev tsim cov nitric oxide thiab/los yog dawb radicals thiaj li yuav rov qab vasodilation. Txij li thaumtetrahydrocurcuminmuaj zog antioxidant zog, nws tuaj yeem tshem tawm cov dawb radicals.
• Cov txiaj ntsig yog dab tsiTetrahydrocurcuminHauv Hypertension?
Txawm hais tias ntshav siab tuaj yeem muaj ntau yam ua rau, feem ntau yog tshwm sim los ntawm cov hlab ntsha ntau dhau, uas ua rau cov hlab ntsha nqaim.
Hauv kev tshawb fawb 2011, cov kws tshawb fawb tau muabtetrahydrocurcuminrau nas kom pom tias nws cuam tshuam cov ntshav siab li cas. Txhawm rau ua kom lub plawv tsis ua haujlwm, cov kws tshawb fawb tau siv L-arginine methyl ester (L-NAME). Cov nas tau muab faib ua peb pawg. Thawj pab pawg tau txais L-NAME, pawg thib ob tau txais tetrahydrocurcumin (50mg / kg lub cev hnyav) thiab L-NAME, thiab pab pawg thib peb tau txaistetrahydrocurcumin(100mg / kg lub cev hnyav) thiab L-NAME.
Tom qab peb lub lis piam ntawm kev noj txhua hnub, covtetrahydrocurcuminpab pawg tau pom qhov txo qis hauv ntshav siab piv rau cov pab pawg uas tsuas yog coj L-NAME. Cov pab pawg uas tau txais koob tshuaj ntau dua tau txais txiaj ntsig zoo dua li cov pab pawg uas tau txais koob tshuaj qis dua. Cov kws tshawb fawb tau ntaus nqi cov txiaj ntsig zoo rautetrahydrocurcuminmuaj peev xwm induce vasodilation.
Post lub sij hawm: Oct-10-2024
