Urothelial carcinoma yog ib qho ntawm cov qog nqaij hlav urinary ntau tshaj plaws, nrog cov qog rov ua dua thiab metastasis yog qhov tseem ceeb ntawm kev kuaj mob. Xyoo 2023, kwv yees li 168,560 tus neeg mob qog noj ntshav yuav kuaj pom hauv Tebchaws Meskas, nrog kwv yees li 32,590 tus neeg tuag; kwv yees li 50% ntawm cov mob no yog urothelial carcinoma. Txawm hais tias muaj cov kev kho mob tshiab, xws li platinum-based chemotherapy thiab PD1 antibody-based immunotherapy, ntau tshaj li ib nrab ntawm cov neeg mob urothelial carcinoma tseem tsis teb rau cov kev kho mob no. Yog li ntawd, nws yog ib qho tsim nyog yuav tsum tau soj ntsuam cov tshuaj kho tshiab los txhim kho cov kev mob tshwm sim ntawm cov neeg mob urothelial carcinoma.
Icariin(ICA), lub ntsiab active ingredient nyob rau hauv Epimedium, yog ib tug tonic, aphrodisiac, thiab anti-rheumatic tsoos suav tshuaj. Thaum noj, ICA yog metabolized rau icartin (ICT), uas ces exerts nws cov teebmeem. ICA muaj ntau yam kev ua ub no, suav nrog kev tswj hwm kev tiv thaiv kab mob, muaj cov tshuaj tua kab mob antioxidant, thiab inhibiting qog nqaij hlav. Xyoo 2022, Icaritin capsules nrog ICT yog cov khoom xyaw tseem ceeb tau pom zoo los ntawm Tuam Tshoj National Medical Products Administration (NMPA) rau thawj kab kev kho mob ntawm kev ua haujlwm tsis zoo ntawm cov kab mob hepatocellular carcinoma. Tsis tas li ntawd, nws tau pom tias muaj txiaj ntsig tseem ceeb hauv kev ua kom ntev tag nrho cov ciaj sia ntawm cov neeg mob uas muaj kab mob siab hepatocellular carcinoma. ICT tsis tsuas yog tua cov qog ncaj qha los ntawm inducing apoptosis thiab autophagy, tab sis kuj tswj cov qog tiv thaiv kab mob microenvironment thiab txhawb kev tiv thaiv qog tiv thaiv kab mob. Txawm li cas los xij, cov txheej txheem tshwj xeeb uas ICT tswj TME, tshwj xeeb tshaj yog nyob rau hauv urothelial carcinoma, tsis to taub tag nrho.
Tsis ntev los no, cov kws tshawb fawb los ntawm Department of Urology, Tsev Kho Mob Huashan, Fudan University tau luam tawm ib tsab xov xwm hu ua "Icaritin inhibits kev loj hlob ntawm urothelial cancer los ntawm suppressing PADI2-mediated neutrophil infiltration thiab neutrophil extracellular trap tsim" nyob rau hauv phau ntawv Journal Acta Pharm Sin B. uasicariintxo cov qog kis thiab kev loj hlob thaum inhibiting neutrophil infiltration thiab NET synthesis, qhia tias ICT tej zaum yuav yog ib qho tshiab NETs inhibitor thiab kho tshiab rau urothelial carcinoma.
Tumor recurrence thiab metastasis yog lub ntsiab ua rau tuag nyob rau hauv urothelial carcinoma. Nyob rau hauv cov qog microenvironment, cov kev tswj tsis zoo molecules thiab ntau lub cev tiv thaiv kab mob subtypes inhibit antitumor tiv thaiv kab mob. Lub inflammatory microenvironment, txuam nrog neutrophils thiab neutrophil extracellular ntxiab (NETs), txhawb cov qog metastasis. Txawm li cas los xij, tam sim no tsis muaj cov tshuaj uas tshwj xeeb inhibit neutrophils thiab NETs.
Hauv qhov kev tshawb fawb no, cov kws tshawb fawb tau pom thawj zaug tiasicariin, kev kho thawj kab rau kev kho mob siab thiab kho tsis tau cov kab mob hepatocellular carcinoma, tuaj yeem txo cov NETs tshwm sim los ntawm kev tua tus kheej NETosis thiab tiv thaiv neutrophil infiltration hauv qog microenvironment. Mechanistically, ICT khi rau thiab inhibits qhov kev qhia ntawm PADI2 hauv neutrophils, yog li inhibiting PADI2-mediated histone citrullination. Tsis tas li ntawd, ICT inhibits ROS tiam, inhibits MAPK signaling pathway, thiab suppresses NET-vim qog metastasis.
Nyob rau tib lub sijhawm, ICT inhibits qog PADI2-mediated histone citrullination, yog li inhibiting transcription ntawm neutrophil recruitment noob xws li GM-CSF thiab IL-6. Nyob rau hauv lem, downregulation ntawm IL-6 qhia ua ib tug kev tswj xyuas voj voog los ntawm lub JAK2 / STAT3 / IL-6 axis. Los ntawm kev tshawb nrhiav rov qab ntawm cov qauv kuaj mob, cov kws tshawb fawb pom muaj kev sib raug zoo ntawm neutrophils, NETs, UCa prognosis thiab kev tiv thaiv kab mob. ICT ua ke nrog cov tshuaj tiv thaiv kab mob tiv thaiv kab mob tuaj yeem muaj kev sib koom ua ke.
Hauv kev xaus, qhov kev tshawb fawb no pom tau tiasicariintxo cov qog kis thiab kev loj hlob thaum inhibiting neutrophil infiltration thiab NET synthesis, thiab neutrophils thiab NETs ua lub luag haujlwm inhibitory hauv cov qog tiv thaiv kab mob microenvironment ntawm cov neeg mob urothelial carcinoma. Tsis tas li ntawd, ICT ua ke nrog anti-PD1 immunotherapy muaj kev sib koom ua ke, tawm tswv yim txog kev kho mob zoo rau cov neeg mob urothelial carcinoma.
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Post lub sij hawm: Nov-14-2024
