Urothelial carcinoma yog ib qho tso zis ntau zaus, nrog cov qog rov ua dua thiab cov duab qhia kev nthuav dav primognescostic yam tseem ceeb. Hauv 2023, kwv yees li ntawm 168,560 tus neeg mob cancer yuav kuaj pom nyob rau Tebchaws Meskas, nrog kwv yees li ntawm 32,590 tuag; Kwv yees li 50% ntawm cov rooj plaub no yog cov tshuaj pleev uralthelial. Txawm hais tias muaj kev kho mob tshiab, xws li Platinum-raws li kev txhaj tshuaj tiv thaiv kab mob, ntau dua ib nrab ntawm cov neeg mob carcinomia tseem tsis teb rau cov kev kho no. Yog li ntawd, muaj kev yuav tsum tau tshawb xyuas cov kev kho tshiab tshiab los txhim kho qhov primnosis ntawm urothelial carcinomial carcinoms cov neeg mob.
Tus iCari(ICA), cov khoom muaj peev xwm nquag muaj nyob rau hauv Epimedium, yog ib tonic, aphrodisiac, thiab anti-rheumatic tsoos tshuaj. Thaum ingested, Ica yog metabolized rau icartin (ICT), uas tom qab ntawd rov ua nws cov kev cuam tshuam. ICA muaj ntau cov kev ua si lom zem, suav nrog kev tswj hwm kev tiv thaiv kev tiv thaiv, muaj cov khoom tiv thaiv kab mob antiox, thiab inhibiting qog. Hauv 2022, Icaritin tshij nrog ICT raws li cov khoom siv tseem ceeb tau pom zoo los ntawm cov kws kho mob hauv zej zog kev ua haujlwm ntawm kev tshaj lij hepatocellular carcinom. Ib qho ntxiv, nws tau pom qhov ua tau zoo tseem ceeb nyob rau hauv lub caij nyoog tag nrho cov ciaj sia ntawm cov neeg mob uas muaj kev lom zem hepatocellular carcinoma. ICT tsis tsuas yog cuam tshuam cov hlav los ntawm kev ua kom lub qog apoptosis, tab sis kuj tau tswj hwm cov qog nqaij tiv thaiv microterviror thiab txhawb nqa cov qog ua tsis tau zoo. Txawm li cas los xij, cov txheej txheem tshwj xeeb uas ICT REPTULATATATURATURATULATES, tshwj xeeb tshaj yog nyob rau hauv Urothelial carcinoma, tsis to taub.
Tsis ntev los no, cov kws tshawb nrhiav los ntawm Department ofology, Hewair University, Fudan University luam tawm cov lus sau "hauv Cov Ntaub Ntawv Kev Nyab Xeeb B. Qhov kev tshawb fawb no qhia tau tiastus iCariTxhaum cov qog sib kis thiab muaj kev nce qib thaum tsis muaj icibe inhibitor thiab kev kho mob tshiab rau kev kho mob uralthelial.
Tum ntsuam xyuas cov kev rov ua dua thiab cov duab qhia tseem ceeb yog qhov ua rau tuag hauv Utothelial carcinoms. Nyob rau hauv lub qog microenviror, tsis zoo cov kev tswj hwm lwg metulation thiab ntau yam tsis muaj zog ntawm cov tshuaj tiv thaiv kab mob antitority. Lub inflammatory microenvironment, txuam nrog neutrophils thiab neutrophil extracellular ntxiab (nets), txhawb cov tum metastasis. Txawm li cas los xij, tam sim no tseem tsis tau siv tshuaj uas tshwj xeeb inhhetrophils thiab nets.
Hauv txoj kev tshawb no, cov kws tshawb nrhiav pom tias thawj zaug uastus iCari, ib txoj kev kho ua ntej kab rau qib siab thiab ua kom muaj kev tiv thaiv kab mob hepatocellular carcinoma, tuaj yeem tiv thaiv netosidal netosis thiab tiv thaiv neutrophil infiltration hauv lub qog mis nyuj microenvironment. ICT khi rau thiab inhibits qhov qhia ntawm Padi2 hauv neutrophils, yog li inhibiting radio2-doldiated cov nplooj ntawv. Ib qho ntxiv, ICT Inhibits Ros ntau tiam neeg, inhibits ntawm Mapk kev piav qhia txoj kev, thiab ua rau cov qog me me metastasis.
Nyob rau tib lub sijhawm, ICT Inhibits Tumor PaCum PDO2-Mediaed cov ntawv sau ua ke, yog li inhibing kev sau ntawv ntawm neutrophil nrhiav cov noob xws li GM-CSF thiab IL-6. Nyob rau hauv lem, downregulation ntawm il-6 hais tawm cov qauv kev tswj hwm kev tawm tswv yim voj voog los ntawm Jak2 / Stat3 / IL-6 axis. Los ntawm kev tshawb xyuas cov tshuaj ntsuam xyuas, cov kws tshawb nrhiav pom qhov sib txuam ntawm neutrophils, nets, UCA kwv yees thiab tiv thaiv plab. ICT ua ke nrog cov tshuaj tiv thaiv kab tiv thaiv kev tiv thaiv tsis pub muaj zog tuaj yeem muaj cov nyhuv snergistic.
Hauv cov ntsiab lus, qhov kev tshawb fawb no pom tiastus iCariTxhaum cov qog sib kis thiab nce zuj zus thaum tsis muaj kev tiv thaiv kev tiv thaiv kev tiv thaiv kev ua yeeb yam ntawm cov neeg mob Tsis tas li ntawd, ICT ua ke nrog kev tiv thaiv kab mob PD1 yuav muaj lub tswv yim zoo rau cov neeg mob uas muaj lub siab
● NewGreen Kev muab khoom tawg Epimedium extractTus iCariHmoov / tsiav tshuaj / pos hniav
Lub Sijhawm Post: Nov-14-2024
