ʻO ka pauda Baclofen maʻemaʻe kūlohelohe kiʻekiʻe ka pauda Baclofen

ʻO Baclofen, i kapa ʻia ʻo Becomphin, Becomphin, a me Li Luxing, ʻo ka inoa o ka lāʻau lapaʻau ʻo chirosol, Liolexin, chloraminobutyric acid, he derivative o ka gamma-aminobutyric acid, kahi lāʻau spasmolytic, no ka hana o ka lolo o ka lolo a me ka iwi iwi spinal cord. mea hoʻomaha ʻiʻo, hoʻomaha. Hiki iā ia ke pale i ka hoʻokuʻu ʻia ʻana o nā waikawa amino excitatory e like me ka glutamic acid a me ka aspartate ma ka hoʻoulu ʻana i ka mea loaʻa, a pēlā e kāohi ai i ka hoʻoili ʻana o ka synaptic hoʻokahi a me ka multi-synaptic reflex i loko o ka lolo a me ka spinal cord o ka ʻōnaehana nūnū waena, i mea e pāʻani ai i kahi. hana spasmotic. Ma ke kino, ua hoʻohana ʻia ma ke ʻano he hoʻomākaukau racemic no ka mālama ʻana i ka spasticity Chemicalbook mai ka waena o 1960s. Ua ʻike pū ʻia nā haʻawina hou e hiki i kēia huahana ke hōʻemi nui i ka gastroesophageal reflux a hoʻomaikaʻi i kāna mau hōʻailona, ​​​​e hoʻomaha maikaʻi i nā hōʻailona o ka dystonia i nā keiki, a mālama i ka maʻi urination ma hope o ka hōʻeha spinal cord refractory. Eia kekahi, hiki i ka noiʻi lapaʻau o ka intrathecal injection therapy ke hoʻomaikaʻi hou i ka pono lapaʻau a hoʻoponopono i ke ʻano o ka lāʻau i kēlā me kēia manawa e hoʻopaʻa i ka hopena therapeutic. I nā makahiki he 10 i hala iho nei, ua holomua nui ka noiʻi lapaʻau o ka baclofen hoʻomaha hoʻomaha ʻiʻo waena, ʻoi aku ka maikaʻi o ka mālama ʻana i ka hoʻoponopono aʻalolo no ka hoʻohaʻahaʻa ʻana i ke kani o ka ʻiʻo a me ka hoʻomaha ʻeha.