Epimedium(Horny Goat Weed) Cire- Icariin Ya Zama Sabon Fata A Yakar Ciwon Urothelial

Urothelial carcinoma yana daya daga cikin cututtukan daji na yoyon fitsari da aka fi sani, tare da sake dawowa da ƙari da metastasis sune manyan abubuwan da za a iya gani. A cikin 2023, za a gano kimanin mutane 168,560 na cutar kansar fitsari a Amurka, tare da mutuwar kusan 32,590; kusan kashi 50% na waɗannan lokuta sune carcinoma urothelial. Duk da samun sabbin zaɓuɓɓukan magani, irin su chemotherapy na tushen platinum da PD1 antibody-based immunotherapy, fiye da rabin marasa lafiya na urothelial carcinoma har yanzu ba sa amsa waɗannan jiyya. Sabili da haka, akwai buƙatar gaggawa don bincika sababbin magungunan warkewa don inganta haɓakar cututtukan cututtukan urothelial carcinoma.

Icarin(ICA), babban sinadari mai aiki a cikin Epimedium, shi ne tonic, aphrodisiac, da magungunan gargajiya na kasar Sin na anti-rheumatic. Da zarar an sha, ICA ta zama metabolized zuwa icartin (ICT), wanda ke yin tasirinsa. ICA tana da ayyuka masu yawa na ilimin halitta, gami da daidaita tsarin rigakafi, samun kaddarorin antioxidant, da hana ci gaban ƙari. A cikin 2022, Icaritin capsules tare da ICT a matsayin babban sinadari an amince da su daga Hukumar Kula da Kayayyakin Kiwon Lafiya ta kasar Sin (NMPA) don maganin layin farko na ciwon daji na hepatocellular mara aiki. Bugu da ƙari, ya nuna tasiri mai mahimmanci wajen tsawaita rayuwar marasa lafiya gaba ɗaya tare da ci-gaban ciwon hanta. ICT ba wai kawai yana kashe ciwace-ciwace ta hanyar haifar da apoptosis da autophagy ba, amma har ma yana daidaita microenvironment na rigakafi da ƙari kuma yana haɓaka martanin rigakafin ƙwayar cuta. Koyaya, takamaiman hanyar da ICT ke sarrafa TME, musamman a cikin carcinoma na urothelial, ba a cika fahimta ba.

Kwanan nan, masu bincike daga Sashen Urology, Asibitin Huashan, Jami'ar Fudan, sun buga labarin mai suna "Icaritin yana hana ci gaban ciwon urothelial ta hanyar danne PADI2-mediated neutrophil infiltration da neutrophil extracellular trap formation" a cikin mujallar Acta Pharm Sin B. Binciken ya bayyana. cewaicarinrage rage yaduwar ƙwayar cuta da ci gaba yayin da yake hana infiltration na neutrophil da NET kira, yana nuna cewa ICT na iya zama sabon mai hana NETs da kuma sabon magani ga urothelial carcinoma.

Komawar Tumor da metastasis sune manyan abubuwan da ke haifar da mutuwa a cikin urothelial carcinoma. A cikin microenvironment na ƙari, ƙananan ƙwayoyin cuta mara kyau da ƙananan ƙwayoyin cuta masu yawa suna hana rigakafi na antitumor. Microenvironment mai kumburi, hade da neutrophils da neutrophil extracellular traps (NETs), yana haɓaka metastasis na ƙari. Koyaya, a halin yanzu babu magunguna waɗanda ke hana neutrophils da NETs musamman.

A cikin wannan binciken, masu binciken sun nuna a karon farko cewaicarin, Jiyya na farko don ci gaba da ciwon ciwon hanta wanda ba zai iya warkewa ba, zai iya rage NETosis da ke haifar da suicidal NETosis kuma ya hana shigar da neutrophil a cikin ƙananan ƙwayoyin cuta. Mechanistically, ICT yana ɗaure kuma yana hana bayyanar PADI2 a cikin neutrophils, ta haka yana hana citrullination na PADI2-mediated histone. Bugu da ƙari, ICT yana hana tsarar ROS, yana hana hanyar siginar MAPK, kuma yana hana ƙwayar ƙwayar cuta ta NET.

A lokaci guda, ICT yana hana ƙwayar ƙwayar cuta ta PADI2-matsakaici histone citrullination, don haka ya hana fassarar kwayoyin daukar ma'aikata neutrophil kamar GM-CSF da IL-6. Bi da bi, downregulation na IL-6 magana yana samar da madaidaicin ra'ayin ra'ayi ta hanyar JAK2/STAT3/IL-6 axis. Ta hanyar nazari na baya-bayan nan game da samfurori na asibiti, masu binciken sun sami dangantaka tsakanin neutrophils, NETs, ​​Uca prognosis da gudun hijira na rigakafi. ICT haɗe tare da masu hana wuraren bincike na rigakafi na iya samun tasirin aiki tare.

A taƙaice, wannan binciken ya gano cewaicarinrage rage yaduwar ƙwayar cuta da ci gaba yayin da ke hana ƙwayar neutrophil da haɗin gwiwar NET, kuma neutrophils da NETs sun taka rawar hanawa a cikin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta. Bugu da kari, ICT hade da anti-PD1 immunotherapy yana da tasirin daidaitawa, yana ba da shawarar dabarun jiyya ga marasa lafiya tare da carcinoma urothelial.